Anti SRP

• CPT Code: 83516
• LOINC: 33921-8
• Specimen Type: red nongel
• Frequency: Setup: Mon-Fri; Analytic time 14 days
• Instructions: 1 ml serum from red nongel, refrigerated or frozen. Alt/ plasma from lavender EDTA tube.
• Text: Signal Recognition Particle (SRP) is a Myositis Specific Autoantibody which is seen in 5-10% of adult and juvenile myositis. Very acute onset of severe polymyositis with frequent myalgias, severe weakness and very high creatine kinase levels. Some adults experience cardiac involvement and palpitations. There is a poor response to therapy.
• Methodology: Immunoprecipitation (IPP)