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Test ID: ZH194

Insulin-Like Growth Factor-1,LC-MS,S

  • CPT Code:
  • LOINC:
  • Specimen Type: SST or Red
  • Frequency: Setup: Sun-Fri; analytic time 2 days
  • Instructions: 0.5mls serum for SST or red. Frozen.
  • Text: Insulin-like growth factor 1 (IGF1) is a 70-amino acid polypeptide (molecular weight kDA; Uniprot Accession P05019 [aa 49-118]). IGF1 is a member of a family of closely related growth factors with high homology to insulin that signal through a corresponding group of highly homologoustyrosine kinase receptors. IGF1 is produced by many tissues, but the liver is the main source of circulating IGF1. IGF1 is the major mediator of the anabolic and growth-promoting effects of growth hormone (GH). IGF1is transported by IGF-binding proteins, in particular insulin-like growthfactor-binding protein 3 (IGFBP3), which also controls its bioavailability and half-life. Noncomplexed IGF1 and IGFBP3 have short half-lives (t1/2) of 10 and 30 to 90 minutes, respectively, while the IGFBP3/IGF1 complex is cleared with a much slower t1/2 of 12 hours. The secretion patterns of IGF1 and IGFBP3 mimic each other, their respective syntheses being controlled by GH. Unlike GH secretion, which is pulsatile and demonstrates significant diurnal variation, IGF1 and IGFBP3 levels show only minor fluctuations. IGF1 and IGFBP3 serum levels,therefore, represent a stable and integrated measurement of GH productionand tissue effect. Low IGF1 and IGFBP3 levels are observed in GH deficiency or GH resistance. If acquired in childhood, these conditions result in short stature. Childhood GH deficiency can be an isolated abnormality or associated withdeficiencies of other pituitary hormones. Some of the latter cases may bedue to pituitary or hypothalamic tumors, or result from cranial radiationor intrathecal chemotherapy for childhood malignancies. Most GH resistance in childhood is mild-to-moderate, with causes ranging from poor nutrition to severe systemic illness (eg, renal failure). Theseindividuals may have IGF1 and IGFBP3 levels within the reference range. Components: Z0418 Insulin-Like Growth Factor 1; Z6978 Z-score for IGF-1
  • Methodology: Liquid Chromatography-Mass Spectrometry (LC/MS)

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