Celiac Associated HLA-DQ Typing

• CPT Code:
• LOINC:
• Specimen Type: ACD Solution B
• Frequency: Setup: Mon-Fri; Analytic time 5 days
• Instructions: 6 mLs whole blood ACD solution B, refrigerated. Do not transfer blood to other containers.
• Text: Most (90%-95%) patients with celiac disease have 1 or 2 copies of HLA-DQ2haplotype (see below), while the remainder have HLA-DQ8 haplotype. Rare exceptions to these associations have been occasionally seen. In 1 study of celiac disease, only 0.7% of patients with celiac disease lacked the HLA alleles mentioned above. Results are reported as permissive, nonpermissive, or equivocal gene pairs. Components: Z6970 DQ alpha 1; Z6971 DQ beta 1; Z6972 Celiac gene pairs present?; Z6973 Interpretation
• Methodology: Polymerase Chain Reaction (PCR)/Sequence-Specific Oligonucleotide Probe (SSO).(PCR is utilized pursuant to a license agreement with Roche Molecu

Components

• Celiac gene pairs present?
• DQ alpha 1
• DQ beta 1
• Interpretation