Test ID: ZG416
Component(s): Z2145 6-TGN LOINC: 32660-3, Z2147 6-MMPN LOINC: 32654-6
CPT code: 80299
LOINC:
Specimen Type: Whole blood EDTA
Frequency: 6 – 12 days
Instructions: 3 mL Whole Blood from Lav (EDTA), Refrigerated. Min 1 mL.
Text: Measures the red-cell concentration of 6-MMP (formed from 6-MP by thiopurine methyltransferase) and also measures the concentration of the resulting 6-TG. Once thiopurine therapy has been undertaken & an equilibrated drug level is achieved (usually 3-6 months), literature suggests that the measurement of thiopurine metabolites is warranted.
Methodology: Whole blood washing and RBC harvesting/counting. Liquid chromatography/tandem mass spectrometry(LC/MS-MS)after acidic hydrolysis