Test ID: ZH244
CPT code: 81287, 88381
LOINC:
Specimen Type: Paraffin Tube
Frequency: 7 – 10 days
Instructions: FFPE tissue block OR 8 unstained slides(5 uM) AND 1 matching H&E slide.Contact LCA for other options&minimum specimen requirements. Ambient.
Text: MGMT is a DNA repair enzyme that is involved in the repair of damage caused by a variety DNA cross-linking compounds, including alkylating agents. Increased methylation of the MGMT gene promoter region causes diminished or silenced expression of the gene, making cells more sensitive to DNA damage.
Methodology: Quantitative methylation-specific polymerase chain reaction (PCR)