New Test Information Index
Will Be Performed at AMS Laboratory October
Screens Will Be Performed at AMS Laboratory
Codes for New ANAs
Laboratory: New ANA Technology
WILL BE PERFORMED AT AMS LABORATORY
OCTOBER 6, 2003
Laboratory has acquired equipment and will perform electrophoresis
testing in-house. Protein electrophoresis on serum, urine,
and spinal fluid as well as immunofixation and hemoglobin
electrophoresis will be offered. This should be a seamless
change for our clients. Specimen requirements, order information,
prices, and CPT codes will not change.
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SCREENS WILL BE PERFORMED AT AMS
LABORATORY SEPTEMBER 7, 2003
in-house test menu for AMS Laboratory now includes Cytology.
This change should also be a seamless change for our clients.
All ordering, coding, and pricing will remain the same.
We hope this expansion will enable us to be more efficient
and will improve service.
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CODES FOR NEW ANAs
screen only - 86038
ANA Screen: If positive, reflex to autoantibodies dsDNA, SSA, SSB, Sm, RNP,
Scl-70, Jo-1, Centromere B, and Histones
ANA screen - 86038
ANA Quantitative - 86039
dsDNA - 86225
SSA - 86235
SSB - 86235
SM - 86235
RNP - 86235
Scl-70 - 86235
Jo-1 - 86235
Centromere - 86235
Histone - 86235
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LABORATORY: NEW ANA TECHNOLOGY
AMS Laboratory has implemented a
new technology, the AtheNA Multilyte,
for autoimmune testing.
The new technology utilizes a patented
microbead technology with a specialized
This is a significant improvement over
the ANA IFA, which is subjective
non-standardized, and may lack SSA/SSB
Traditional autoimmune testing often involved
performing an ANA screen, performing IFA,
and performing individual autoantibody
based on the patterns and titers.
The new technology performs the ANA
screen and nine additional autoantibodies:
Numeric results are available for
a specific antibody (or antibodies)
at the same time
the ANA screen result is available,
because all the assays are performed
simultaneously. This technology offers significant benefits in turn
time and interpretation. The presence
of characterized autoantibodies in
with a positive ANA result and symptomatology can have far greater
than an uncharacterized ANA result alone.
A recent paper submitted at the AACC meeting in Orlando compared
this test system, the AtheNA Multilyte, to consensus outcome of multiple
IFA and ELISA
systems. Concordance of the individual markers of the AtheNA Multilyte
compared to the consensus of the reference methods was:
It is well known that the AMA and
HCFA are averse to automatic reflex
testing. This is do to concerns that stem from eliminating the
intervention in determining the tests performed. Future forms will
address this issue
by offering the physician two boxes.
] ANA:Screen only
] ANA Screen: If positive, reflex to
autoantibodies dsDNA, SSA, SSB,
Sm, RNP, Scl-70,Jo-1, Centromere B, and Histones.
special form will be required for the new ANA reflex test
until new requisitions are printed.
Traditional cut points for ANA titers are usually a 1:40 titer
is not significant, while a 1:80 titer is significant. The new
will report numerical
results with a cut point of 100. Values below 100 are not significant
and values greater
than 100 are positive. The reporting format will list negative
and positive results in different columns, so results will be easy
For positive patients, you will receive screen results plus the
individual autoantibodies that are positive. Results will be available
AMS Laboratory will begin using the AtheNA Multilyte ANA test system
October 6, 2003. If you have any questions or concerns please feel
free to contact
Bill Combs at 316-858-8804.
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